The study showed a trend toward higher early recanalisation rate and clinical recovery, but was stopped prematurely by the sponsor, because three patients died in the group treated with iv tPA plus ultrasound plus microbubbles, indicating a possibly increased risk of symptomatic bleedings with this combination [ 22 ].
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A pragmatic approach to sonothrombolysis in acute ischaemic stroke: the Norwegian randomised controlled sonothrombolysis in acute stroke study (NOR-SASS).
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