Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits.

The prevalence of metabolic vitamin B12 deficiency [Fedosov’s wellness quotient ω < −0.5] in our cross-sectional survey, within the three age groups 60–69, 70–79 and ≥80 year were significantly different and showed a significant trend (p < 0.001 for both) as follows: 8.0 % (37/426), 13.4 % (55/356) and 19.0 % (35/149).

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Using a linear regression model employing age, serum folate, vitamin B12, gender and eGFR as independent and Hcy or MMA as dependent variables revealed a highly significant (p < 0.001) inverse relationship of both Hcy and MMA with eGFR.

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