Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients.

Sci Rep · 2015 · PMC4499815 · PMID 26165383

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantP = 1.63 × 10 −8actually significant

Gene-based analysis supported the involvement of TRAF2 , MAP2K4 , and MAP3K5 as mediating complications risk and a highly significant trend was identified between the number of risk genotypes and complications risk (P = 1.63 × 10 −8 ).

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reached borderline significanceP < 0.1so close (0.05 < p ≤ 0.1)

Two other SNPs, both in MAP3K5 , reached borderline significance (P < 0.1) in the replication population with similar effects as the discovery population: rs9389421 (P = 0.063) and rs13195420 (P = 0.055).

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