In consideration merely of the pioglitazone-induced effects, the number of EPC was not affected (p=0.09), although it showed a trend to increase.
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Pioglitazone and Endothelial Dysfunction: Pleiotropic Effects and Possible Therapeutic Implications.
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The sentences
Knowing that NO is the most important endothelium-derived relaxing autacoid and that there is a positive correlation among insulin and the up-regulation of eNOS [ 7 ], the additional mechanisms related to the activation of PPARy may be significant for cardiovascular disorders linked with diabetes mellitus, too.