Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness.

Lastly, in support of the above observations, depletion of tuberin expression by a short-hairpin RNA transduced into breast cancer cells with wild-type TSC2 , MCF7, revealed a significant change in the expression of the lung metastasis signature ( P = 0.002); thus, genes that when up-regulated mediate lung metastasis showed a trend to be up-regulated with tuberin depletion, and the opposite trend was observed for the down-regulated set ( Fig 1F ).

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