Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Upon 4T1 inoculation in WT mice, the relative numbers of these cells were either enhanced (tumour-draining lymph nodes) or reduced (blood and spleen), but in δ D910A mice showed a trend towards expansion ( Extended Data Fig. 1a ), indicating that δ D910A mice are capable of mounting both CD4 + and CD8 + T cell responses against 4T1 tumours.

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