NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5.

Int J Oncol · 2015 · PMC4501659 · PMID 26044191

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After co-treatment, a decrease in Noxa levels resulted in a statistically significant decrease in cell toxicity, while Mcl-1 knockdown showed a trend toward increased death after co-treatment.

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