Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.

Additionally, we observed a strong trend toward a transient increase in CSF muHTT protein in Hu97/18 CSF following striatal injection of the neurotoxin quinolinic acid (QA) ( Fig. 4D ).

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This effect failed to reach significance due to high inter animal variability, which is likely due to surgical and neurodegenerative variation.

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