Heat shock response and autophagy--cooperation and control.

In our recent studies, strenuous treadmill running (rectal temperature of 40°C) produces a time-dependent increase in HSP70 protein expression in peripheral leukocytes, but the difference did not reach statistical significance. 5 Similarly, a short (4 min) bout of “all-out” cycling results in a nonsignificant increase in HSP70 protein expression in monocytes and lymphocytes. 145 On the contrary, running in a hot environment (40°C) with body temperature exceeding 39°C results in a significant increase in HSP70 in PBMCs within 1 h after exercise 146 following an increase in HSP70 gene 147 and transcript expression. 148,149 Exhaustive endurance exercise has been consistently shown to trigger heat stress response in human leukocytes.

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