Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints.

Placing diabetic rats on a normal diet for 12 weeks, after 12 weeks of the high fat diet and 4 weeks of hyperglycemia, had a modest effect on glucose clearance ( Figure 1(b) , AUC: 144% of control, P < 0.05 compared to control rats) but the difference between diabetic rats and diabetic rats placed on the normal diet did not reach statistical significance.

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