Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life.

In the asphyxiated newborns treated with hypothermia who developed or did not develop later brain injury, the ADC values ( Table 2 ) were significantly decreased on day 1 of life and on days 2-3 of life in the different regions of interest (thalamus, posterior limb of internal capsule, lentiform nucleus, and anterior white matter, as well as frontal cortical grey matter) when compared with the healthy newborns; the same trend was observed in the posterior white matter, but it did not reach statistical significance.

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