Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.

Despite these inherent constraints, transfer of human NLV-specific T cells led to prolonged survival, which was modest at very high initial virus burden and did not reach statistical significance ( Fig 7A ) but was highly significant (P < 0.001 by log-rank test as well as by Gehan-Wilcoxon test) at a moderate, more realistic, initial virus dose ( Fig 7B ; see Discussion ).

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With the exception of the liver, where a tendential reduction in day 11 median virus titer did not reach statistical significance due to high variance in the therapy group, infectious virus load was found to be significantly reduced in spleen (P < 0.001) and lungs (P = 0.014) by 10 7 CD8-TCR NLV cells but not by 10 7 CD4-TCR NLV cells (P >0.05 throughout).

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