Pregabalin and placebo responders show different effects on central pain processing in chronic pancreatitis patients.

In contrast, the placebo responders showed a nonsignificant trend for a decrease in CPM response, which is a less effective response (more pro-nociceptive pain modulation), after 3 weeks of treatment ( P =0.028) ( Table 2 ).

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With treatment, pregabalin responders’ descending pain modulation (CPM response) became significantly more inhibitory, whereas that of placebo responders showed a trend toward becoming more facilitatory.

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