Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.

When compared to control rats, a weak trend for a higher TnI phosphorylation was found in diabetic rats (~30% higher, P = 0.1254, Additional file 1 : Figure S2e), while TnI phosphorylation was similar to that of control group levels in fasudil treated diabetic rats (Additional file 1 : Figure S2e).

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LV ROCK2 expression (Figure 2 a) was elevated ~2.5-fold in diabetic rats, although this did not reach statistical significance (0.015 ± 0.005 vs. 0.006 ± 0.005 AU, Figure 2 c).

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