Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis.

Western blotting and raw quantitation of TDP-43 in this fraction revealed a strong trend toward down-regulation of TDP-43 protein in myc-H5 transfected cells relative to empty vector controls (myc-H5 = 0.73 ± 0.05%, empty vector = 1.0 ± 0.11, N = 5 per group, P = 0.06) ( Fig. 6 G,H).

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