Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators.

There were no changes to gene expression that achieved genome-wide significance, although the analysis revealed two genes with nominally significant expression changes ( P ∼ 0.01 before correction for multiple hypothesis testing), including MUC4 and HRC that were induced 1.8-fold and 1.7-fold, respectively.

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