Extracellular signal-regulated kinases 1/2 as regulators of cardiac hypertrophy.

The Erk2 +/– heterozygous mice did show significant reductions in fractional shortening after TAC compared with wildtype mice and Erk1 –/– mice showed a trend toward reduced function, showing that while ERK1/2 activity may not be necessary for concentric hypertrophy, it does play a role in the process.

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