Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome.

We observed no differences in expression in any of the insulin signaling pathway elements, although there was a trend towards significance for INSR ( P = 0.094), with PCOS women demonstrating decreased INSR expression versus controls.

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In addition, one possible reason for the lack of expression differences is that our cases and controls were generally similar with respect to their insulin dynamics; only fasting glucose approached significance, whereas differences in fasting insulin, HOMA-IR and HOMA-%B were insignificant.

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