Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.

Compared to controls, non-activated and CD3+CD28-activated CD4 + T cells from patients showed a trend toward reduced respiration and glycolysis ( Figure 1 Ci), and the increase in OCR and ECAR levels upon CD3+CD46 activation—which was present in all HDs—was absent in CD46-deficient individuals ( Figure 1 Ci).

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