IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.

Depletion of CD4 + , but not CD8 + , T cells significantly reduced plasma levels of IFN-γ and TNF-α in infected IL-27R -/- mice (p<0.001 or <0.05), although the reduction of IL-12p40 did not reach statistical significance ( Fig 6C ).

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