Amyloid PET in European and North American cohorts; and exploring age as a limit to clinical use of amyloid imaging.

The mean regional SUVR values for PIB and Florbetapir across the ROIs examined ( n = 12) were significantly correlated in the HC (ρ = 0.671, p = 0.02, R 2 = 0.795), MCI amyloid-positive patient (ρ = 0.902, p < 0.001, R 2 = 0.738) and AD patient (ρ = 0.853, p < 0.001, R 2 = 0.778) groups, but not in the MCI amyloid-negative patient groups although a clear trend was observed (ρ = 0.531, p = 0.08, R 2 = 0.782) (Fig. 4a ).

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