Barely Significant
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Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer.

PLoS One · 2015 · PMC4523174 · PMID 26237329

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an increasing trendno p-value reported
An increasing trend of ACOXL protein expression loss in more poorly differentiated and aggressive tumors was also noted.

also in 63,971 other papers

showed a trendno p-value reported
Separating the tumor category into Gleason grades and metastatic tumors showed a trend for decreased ACOXL expression in more advanced and aggressive tumors.

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.