Besides a regional change trending towards significance upstream of HLA-DOA , none of the associations estimated on the array replicated in the independent cohort (Table 1 ).
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Epigenome-wide and transcriptome-wide analyses reveal gestational diabetes is associated with alterations in the human leukocyte antigen complex.
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In contrast, pyrosequencing of these regions in the HEBC identified significant differential methylation of similar magnitude to the changes estimated on the methylation array proximal to our four candidates and among surrounding loci (with a trend towards significance for the locus within HLA-H/HLA-J ), thus verifying the array findings.