Leveraging an Electronic Health Record-Linked Biorepository to Generate a Metformin Pharmacogenomics Hypothesis.

AMIA Jt Summits Transl Sci Proc · 2015 · PMC4525256 · PMID 26306225

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marginally significantno p-value reported

Gene-level and SNP-level analysis identified marginally significant associations for FMO5 variation, representing an EHR-driven pharmacogenetics hypothesis for a potential novel mechanism for metformin biotransformation.

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of marginal significanceno p-value reported

While the FMO5 gene appeared to be of marginal significance in relation to glycemic response to metformin, our secondary hypothesis for the remaining FMO genes demonstrated no significance.

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