Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes.

A disadvantage of including only the most highly significant and replicated SNPs is that there may be many other SNPs with true effects that do not reach the stringent genome-wide significance levels.

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Prior to inclusion in the GRS, SNPs identified in the EA or East Asian meta-analyses were screened to have at least nominally significant associations with BP in the Han Chinese sample.

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With these limited, sometimes conflicting results, more work is needed to verify whether inclusion of additional marginally significant SNPs in GRSs is the best approach for cardiovascular traits.

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