Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.

ARID5B variants (rs2588969 and rs494288) showed marginally significant association with LOAD in meta-analysis of 2,634 LOAD and 4,201 controls ( P = 0.046 and 0.008, respectively), although the associations did not survive adjustment for covariates ( P = 0.30 and 0.11, respectively).[ 19 ] Other inconclusive association of ARID5B variants included Naj et al.

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Another variant (rs17009220, P = 0.00484, http://www.gwascentral.org/marker/HGVM16286779/results?t=2 ) in WDFY3 exhibited nominally significant interaction (SNP* APOE ε4) in an AD case-control GWAS study.[ 27 ] GFRA1 gene, which encodes GDNF family receptor alpha 1, a member of the GDNF receptor family, is among the few genes with suggestive association to rate of cognitive decline in the LMCI subgroup.

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