The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α -Synuclein Levels in Parkinson's Disease: A Meta-Analysis.

These studies had highly significant heterogeneity ( P < 0.00001, I 2 = 91%), so a random-effect model was used to calculate pooled SMD.

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Forest plot ( Figure 6 ) showed that the diamond was on the left side of vertical line and infinitely close to it, which demonstrates that the mean concentration of CSF α -syn was slightly decreased in PD compared to PSP, and the difference was marginally significant (SMD: −0.57, 95% CI: [−1.14, −0.00], Z = 1.97, P = 0.05). 3.7.

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Several studies have explored the potential use of α -syn as a PD diagnostic biomarker in human CSF, but the results are inconsistent: some studies have shown a clear trend of lower total CSF α -syn in PD and other types of Parkinsonism such as MSA, DLB, and PSP, whereas others show no significant variation.

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