miRNA-122 showed elevated levels in exosomes isolated from patients with alcoholic hepatitis, but it did not reach statistical significance (Fig. 5 d).
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Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis.
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miRNA-192, miRNA-122 and miRNA-30a accurately discriminate the alcohol-fed and control mice Consistent with the highly significant increase of miRNA-122, miRNA-30a, and miRNA-192 (Fig. 4 a–c), those miRNAs showed promising diagnostic values.