Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression.

After correcting for the number of exons interrogated (116,528), an adjusted p-value < 0.05 was observed for two out of six exons (Exon 5 and Exon 6) within the gene ITM2B with a further two exons (Exon 3 and Exon 4) approaching significance.

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Our GWAS analysis also suggested a genetic basis to ASI through the identification of a SNP of genomewide significance and a further eight SNPs of near significance occurring within the coding region of the binding protein, fox-1 homolog (RBFOX1) gene (see Fig 2A and 2B , Table 1 ).

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