Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity.

However, in the final joint analysis of all genotyped subjects two SNVs, rs62623713 and rs35923425 ( NM_024727 :c.G1134C:p.L378F), showed nominally significant association with obesity in 1917 morbid obese and 1278 never-obese controls, with a P -value of 0.0063 (odd ratio (OR)=1.32, MAF 0.081 in obese and 0.063 in controls) or a P -value of 0.004 (OR=1.35, MAF 0.076 in obese, 0.058 in controls), respectively ( Table 3 ). rs62623713 located at 110 019 439 base pair (bp) on chromosome 1 (hg19) is a missense variant in exon 4 of the SYPL2 gene. rs35923425 located at 169 569 432 bp on chromosome 3 is also a missense variant in exon 7 of the leucine-rich repeat containing 31 ( LRRC31 ) gene.

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