Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes.

In the RNA-Seq data, TET3 showed a trend for differential expression in the SGA placentas (DESeq: P = 0.0029; DESeq2: P = 0.00035).

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As the effect sizes for the majority of these genes were small (<1 SD) and close to significance cutoff, it may explain the limitations in replicating these findings in our smaller sample set.

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Promoter regions of 77 genes (44.5%) with highly significant decrease in placental expression in PE contain potential response elements for all three TFs.

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