Among the nominally significant loci, there are 16 regions that overlap with gene exons ( Table 3 ) which are very likely to have direct impact on the gene products.
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CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations.
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Our protein-protein interaction network search detected its predicted interactions with a group of kinesin family members and microtubule associated proteins, which resulted in the highly significant enrichment of GO biological processes of “microtubule-based movement” and “microtubule-based process.” The mouse homolog of AKNAD1 has not been well characterized, but similar functional interaction network searches also yield a group of predicted functional partners enriched in endoplasmic reticulum related processes.