Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.

Lastly, we examined levels of the ubiquitin-like protein, p62/SQSTM1, and despite the modest increase in SQSTM1/p62 within the substantia nigra and striatum, it did not reach statistical significance compared with vehicle treatment ( Fig. 6E ).

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