Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation.

There was a borderline significant interaction between ob genotype and PhIP treatment ( P = 0.049).

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Glucose Tolerance Test (GTT) and Nonfasted Blood Glucose Based on the AUC values from the GTT test performed at 6 weeks of age, AUC in Apc Min/+ mice were higher than in Apc +/+ mice, and AUC in PhIP-treated mice was higher than in 0.9% NaCl-treated mice; however, these comparisons did not reach statistical significance.

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