Prevention of Morbidity in sickle cell disease--qualitative outcomes, pain and quality of life in a randomised cross-over pilot trial of overnight supplementary oxygen and auto-adjusting continuous positive airways pressure (POMS2a): study protocol for a randomised controlled trial.

Pain frequency, defined as the number of days that pain was experienced in a 2 - week period, improved in the treatment arm ( p = 0.07) but this did not reach statistical significance, perhaps related to reduced statistical power due to reluctance to complete paper pain diaries (full data was only available for 8 of the 12 participants in each arm) [ 37 ].

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