Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes.

Muscle fiber histology As expected from previous results of lambs with spontaneous MSTN mutations [ 37 ], histological analyses of muscle biopsies showed muscle fibers of lower diameter although due to the relatively low number of homozygous KO animals analyzed (n = 4) it did not reach statistical significance when compared to WT animals (data not shown).

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