Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.

On the other hand, the number of oxidative fibres was significantly increased by 28% in heterozygous and was also increased by 12% in the muscle of homozygous knockout mice, although the latter did not quite reach statistical significance (analysis of variance; P =0.1).

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Although genes with known higher expression in oxidative fibres, including PGC-1α and RIP140, were tended to be increased in the quadriceps, EDL and soleus muscles on reduction of Tbx15, these results did not reach statistical significance.

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