Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.

While PEA-15 -deficient and wt T cells exhibited similar levels of T-bet, GATA-3 and FoxP3, RORc seemed to be expressed at higher levels in PEA-15 -deficient T cells although this difference did not reach statistical significance ( Fig 4 ; panel B).

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