Methylprednisolone in the management of spinal cord injuries: Lessons from randomized, controlled trials.

1.9%, respectively), though these associations did not reach statistical significance.[ 7 ] NASCIS II, 1990 was a multicenter, double-blinded RCT that randomized 487 patients with acute traumatic SCI to three arms: (1) 30 mg/kg bolus followed by 5.4 mg/kg for 23 h; (2) naloxone 5.4 mg/kg bolus followed by 0.5 mg/kg/h for 23 h; and (3) placebo.

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