highly significantP<0.0001
The two-way ANOVA test detected highly significant inter-group differences with respect to 4-HNE (F=27.34; P<0.0001), and the posthoc Bonferroni test demonstrated significantly higher mean levels of 4-HNE in the ethanol+vehicle (P<0.01) and ethanol+PPAR-γ agonist (P<0.001) treated relative to corresponding controls.