Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

The most strongly associated SNP (rs804279) was intergenic, approached genome-wide significance in the Stage 1 Discovery GWAS (A allele, OR=0.74, 0.66–0.83 95%CI, logistic regression P =1.4 × 10 −6 ), and was nominally significant in the Stage 2 Metabochip Replication (A allele, OR=0.82, 0.73–0.93 95%CI, logistic regression P =2.7 × 10 −3 ) for a sample-size weighted two-strata meta-analysis P meta =1.9 × 10 −8 .

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