Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.

Nat Commun · 2015 · PMC4557297 · PMID 26095772

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0.0740

closest p · 1.5× alpha

0.0740

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did not reach statistical significanceP -values=0.074so close (0.05 < p ≤ 0.1)

Genes whose promoters bore H2AK119Ub alone or both H3K4me3 and H3K27me3 also showed an increase, which however did not reach statistical significance ( P -values=0.074 and 0.41, respectively, determined using the two-tailed Mann–Whitney U -test).

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