Analysis of cytochrome b(5) reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence.

This strain also displayed an increase in the relative abundance of trihydroxy 18:0 (t18:0) that was approaching significance at the 5% level ( p = 0.054) ( Fig. 7 ). 3.7 Δ ZtCBR1 - 1 displays an altered sterol profile In order to assess the effect of ZtCBR1 ablation on sterol biosynthesis, the sterol profile of the WT and Δ ZtCBR1 - 1 strains were analysed using GC–MS. Δ ZtCBR1 - 1 displayed a significant reduction in the relative abundance of the final product of the sterol pathway, ergosterol (ergosta-5,7,22-trienol), relative to the WT ( p < 0.001).

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