In the same way that a dramatic deviation from an overall trend of a metabolite’s concentration is identified as measurement error via smoothing spline regression, the deviations of many metabolites in one sample can be identified as the result of reference error or a dilution effect.
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A correction method for systematic error in (1)H-NMR time-course data validated through stochastic cell culture simulation.
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The sentences
No change of less than 10 % can be observed as this value had been chosen as a cutoff for separating compounds with a significant trend.