Therapeutic potential of folic acid supplementation for cardiovascular disease prevention through homocysteine lowering and blockade in rheumatoid arthritis patients.

Of particular relevance, a recent meta-analysis of 26 randomized double-blind placebo-controlled studies including 58,804 subjects reported a strong trend in the reduction of future stroke risk of 7 % (RR 0.93, 0.86 to 1.00; p = 0.05) with folic acid supplementation [ 55 ].

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