DNA damage in B and T lymphocytes of farmers during one pesticide spraying season.

Among potential confounding factors, no significant association was observed between DNA damage and current smoking status (Wilcoxon’s test, P = 0.41 for B lymphocytes and P = 0.78 for T lymphocytes) nor with alcohol consumption (Wilcoxon’s test, P = 0.25 for B lymphocytes and P = 0.21 for T lymphocytes), even if a slightly decreased level of DNA damage (25 and 30 % for B and T lymphocytes, respectively) was observed for daily drinkers with a borderline significant negative correlation with the quantity of alcohol expressed in g per day for T lymphocytes ( P = 0.06, ρ = −0.46).

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However, median OTMs of B lymphocytes showed a trend to be slightly higher in the FO group than in the non-exposed group during P0 (relative median OTM = 1.53 in the FO group versus 1.30 in the non-exposed group, P = 0.12).

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