Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.

( 16 ) However, we believe that our results failed to reach statistical significance because the rate of symptom relief in the placebo group in the present study was very high (61.9%), compared with that in previous studies (approximately 40%).

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