Co-IPs extended the FRAP results, revealing more stable APC2ΔSAMPs:Axin interaction when R2 was deleted ( Figure 6C ; quantified in Figure 6D ; the change after deleting motif B and the SAMPs did not reach statistical significance).
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A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.
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