Also consistent with the interaction data, loss of PC showed a trend towards activation of all three GTPases ( Fig 4 ), with a significant increase in Rac1 activation, while loss of PD led to increased activation of Rac1 ( Fig 4 ).
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RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin.
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