Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin in Japanese Patients with Type 2 Diabetes Mellitus.

In canagliflozin-treated groups, although an increasing trend was observed in the 24-h urine volume on Day 1, this increase soon declined toward baseline levels despite the sustained UGE increase, which is similar to previously reported findings [ 22 ].

also in 63,971 other papers

The change in urine osmolality over time from baseline on Day 1 showed a trend toward an increase in the canagliflozin-treated groups, whereas no change in osmolality was observed in the placebo group (Fig. 5 c).

also in 53,322 other papers